Cat Scratch Neuroretinitis: About a Case

Abstract

<p>Cat scratch disease is a zoonosis distributed throughout the world where cats are the primary reservoir of Bartonella henselae, with the cat flea (Ctenocephalides felis) as the primary vector among them. Such disease is characterized by predominantly systemic manifestations in the brain, eye, liver, spleen, and bone. We present the case of a 29-year-old female patient who consulted for decreased visual acuity (VA) and pulsatile eye pain of intensity 8/10 according to the visual analog scale (VAS) in the left eye (LE), without symptoms nor clinical manifestations in the right eye (RE). She presented associated symptoms like unquantified fever and neck pain. The ophthalmological clinical examination revealed a vascularized optic disc with poorly defined edges, concomitant macular edema, retinal thickening, and lipid exudates in the central 6 mm, with a clinical presentation associated with a macular star. Fluorescein angiography (FAG) revealed papillary hyperfluorescence by staining in the arterial phase and optical coherence tomography (OCT), with an altered internal retinal profile and architecture. Serology was positive for Bartonella henselae (IgG 1: 256; IgM 1:32). The timely recognition of ocular signs and clinical support through diagnostic images favors resolution and visual recovery through pharmacological management with antibiotics and anti-inflammatories.</p>
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References

Okaro U, George S, Anderson B. What is in a cat scratch? Growth of bartonella henselae in a biofilm. Microorganisms. 2021;9(4): 1-14. Disponible en: https://doi.org/10.3390/microorganisms9040835

Ksiaa I, Abroug N, Mahmoud A, Zina S, Hedayatfar A, Attia S, et al. Update on Bartonella neuroretinitis. J Curr Ophthalmol. 2019;31(3): 254-261. Disponible en: https://doi.org/10.1016/j.joco.2019.03.005

Abdelhakim A, Rasool N. Neuroretinitis: a review. Curr Opin Ophthalmol. 2018;29(6): 514-519. Disponible en: https://doi.org/10.1097/ICU.0000000000000527

Cervi Rosa PA, Nakayama LF, Campos Bergamo V, Kondo Kuroiwa DA, Bueo de Moraes NS. Bartonella hanselae retinitis patient evaluated with multimodal retinal exams. Int J Retin Vitr. 2020;6(1): 54. Disponible en: https://doi.org/10.1186/s40942-020-00257-6

Pérez R, Fischman A, Poblete MJ, Vizcaya C, Perret C, García C, et al. Infección atípica y neurorretinitis por Bartonella henselae en una unidad de hospitalización pediátrica: comunicación de tres casos. Rev Chil Infectol. 2020;37(4): 463-469. Disponible en: https://doi.org/10.4067/S0716-10182020000400463

Del Valle Welschen DV. Neurorretinitis por Bartonella henselae: presentación de un caso y revisión de la literatura. Rev Mex Oftalmol. 2016;90(5): 235-241. Disponible en: https://doi.org/10.1016/j.mexoft.2015.06.007

Johnson A. Ocular complications of cat scratch disease. Br J Ophthalmol. 2020;104(12): 1640-1646. Disponible en: https://doi.org/10.1136/bjophthalmol-2019-315239

Yap SM, Saeed M, Logan P, Healy DG. Bartonella neuroretinitis (cat-scratch disease). Pract Neurol. 2020;20(6): 505-506. Disponible en: https://doi.org/10.1136/practneurol-2020-002586

Eloubeidi DM, Kilpatrick DL, Crosson JN. Branch retinal artery occlusion secondary to Bartonella henselae infection in a 13 year-old. Am J Ophthalmol Case Reports. 2020;19: 100734. Disponible en: https://doi.org/10.1016/j.ajoc.2020.100734

Eiger-Moscovich M, Amer R, Oray M, Tabbara KF, Tugal-Tutkun I, Kramer M. Retinal artery occlusion due to Bartonella henselae infection: a case series. Acta Ophthalmol. 2016;94(5): e367-e370. Disponible en: https://doi.org/10.1111/aos.12932

Wyler J, Meyer Sauteur PM, Zbinden R, Berger C. Improved diagnosis of cat-scratch disease with an IgM enzyme-linked immunosorbent assay for Bartonella henselae using N-lauroyl-sarcosine-insoluble protein antigen. Clin Microbiol Infect. 2020;26(9): 1271-1273. Disponible en: https://doi.org/10.1016/j.cmi.2020.04.044

Kalogeropoulos D, Asproudis I, Stefaniotou M, Moschos MM, Mentis A, Malamos K, et al. Bartonella henselae- and quintana-associated uveitis: a case series and approach of a potentially severe disease with a broad spectrum of ocular manifestations. Int Ophthalmol. 2019;39(11): 2505-2515. Disponible en: https://doi.org/10.1007/s10792-019-01096-7

Nawrocki CC, Max RJ, Marzec NS, Nelson CA. Atypical manifestations of cat-scratch disease, United States, 2005-2014. Emerg Infect Dis. 2021;26(7): 1438-1446. Disponible en: https://doi.org/10.3201/eid2607.200034

Fairbanks AM, Starr MR, Chen JJ, Bhatti MT. Treatment strategies for neuroretinitis: current options and emerging therapies. Curr Treat Options Neurol. 2019;21(8): 36. Disponible en: https://doi.org/10.1007/s11940-019-0579-9

Keywords

Retinal disease
macula lutea
Bartonella infections
cat scratch disease
optic neuritis
serology