Effect of the topic ketotifeno fumarato on the total concentration of IgE in tears and the expression of HLA-DR in conjunctivitis allergic patients

Abstract

Allergic conjunctivitis is a hypersensitive type I or immediate by the IgE ands its effect regarding the liberation and activation of inflammatory mediators by mastocitos. The purpose was to determine the presence of symptomatology and IgE total concentration in tears before and after treatment with ketotifeno fumarato in conjunctivitis allergic patients. 12 conjunctivitis allergic patients attended to the Optometric Research Institute of the Universidad de La Salle, and an ophthalmological exam was carried out and a total IgE in tears was determined. These patients were treated with zaditem 0.025%, a tear every 12 hours, for a month. At the end of this treatment an ophthalmological exam was carried out again, the IgE was determined, as well as the presence of HLA-DR in an impression cytology. Results found that conjunctivitis allergic patients had signs and symptoms such papillas, pruritus, edema, ardor and hyperemia, the IgE levels were higher to 5UI/1 with a measure of 23.75 UI/1. After the treatment with zaditen there were no symptomatology and the IgE levels significantly decreased (t= 3.30) with a P