Effect of Autologous Serum in the Repair of the Ocular Surface Associated with Dry Eye

Abstract

The ocular surface damage associated with the alteration of the tear film causes multiple symptoms, and autologous serum is used as treatment. Objectives: To compare the effect of autologous serum on the ocular surface repair, prepared with two different concentrations (80 y 20 %). Materials and methods: A quasi-experimental prospective study was carried out in 25 patients diagnosed with dry eye through the Schirmer test, tbut and Rose Bengal staining. Autologous serum eye drops wereadministered to 80% in the right eye and 20% in the left eye, and after 30 days of application, tests were once again performed. For the preparation of autologous serum, ethical procedures were performed and the standardized protocol at the University of Lübeck, Germany, was followed according to the Bundesärztekammer guide and the Paul Ehrlich Institute. Results: The application of autologous serum to 80% and 20% showed a significant increase in both tear volume (Schirmer)and tear stability and quality (tbut) and, additionally, ocular surface repair is achieved. No significant differences were found with the two concentrations but with higher concentrations a greater effect on production and time of rupture of the tear film is achieved (p<0.080). Conclusions: The administration of autologous serum as a treatment for dry eye presents repair on the ocular surface in both concentrations of 80% and 20%.