Resumen
El glaucoma es la principal causa de ceguera irreversible en todo el mundo. En resumen, es una neuropatía óptica progresiva multifactorial que se correlaciona con la muerte de las células ganglionares de la retina, trastornos de la cabeza del nervio óptico y desórdenes del campo visual. Recientemente se ha reportado que el acetato de leuprolida tiene propiedades neurotróficas, el objetivo de este trabajo fue determinar si su administración sistémica retrasa el proceso neurodegenerativo en un modelo experimental de glaucoma. Se incluyeron ratas Wistar divididas en tres grupos: 1) un grupo de control, 2) un grupo de glaucoma inducido por ácido hialurónico y 3) un grupo de glaucoma inducido por ácido hialurónico tratado con acetato de leuprolida intramuscular. Las respuestas eléctricas oculares a la luz se registraron mediante electrorretinografía simultánea de campo completo y los ojos se procesaron para el estudio histológico. Los resultados mostraron una mejora en la actividad eléctrica, una recuperación de fibras del nervio óptico, así como una reducción de la astrogliosis reactiva en el grupo tratado con acetato de leuprolida. En definitiva, el acetato de leuprolida es una nueva y potencial alternativa de tratamiento en el glaucoma, ya que frena el proceso neurodegenerativo.Referencias
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Palabras clave
baja visión
neurotrófico
regeneración