Conjunctivitis and Ophthalmological Approach in Patients with COVID-19: A Systematic Review of the Literature

Abstract

The current study aims to report the frequency and therapy used for treating symptoms associated with conjunctivitis in confirmed COVID-19 patients in clinical practice since the appearance of the virus. As materials and methods, a systematic review protocol was developed based on the Prisma statement. Also, articles for review were identified using Google Scholar, Medline (Pubmed), Embase, and Web of Science. The bibliographic search identified 2815 results. After complete reading, 14 articles were selected since they included information on the frequency of symptoms associated with conjunctivitis in positive patients for COVID-19. 8 case reports, 4 case series, and 2 cross-sectional studies were analyzed, of which 8 (57.14%) studies reported ocular treatment. The frequency of conjunctivitis in confirmed COVID-19-positive patients in respiratory and tear samples was 52/865 (6.01%). In contrast, corneal involvement was related to superficial punctate keratitis and pseudodendrites, only in 2/865 (0.23%) patients. The experience in the clinical approach has been examined with oral and topical antivirals (vanciclovir, ganciclovir, ribavirin), ocular lubricants, and topical antibiotics (moxifloxacin), with the resolution of symptoms and absence of subsequent complications.
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Keywords

SARS-CoV-2
COVID-19
conjunctivitis
conjunctiva