Abstract
Based on a literature review, this research aims to identify the associated factors affecting the population with diabetic retinopathy (DR). To do so, an online search for scientific papers was carried out in the databases Medline (PubMed) and LILACS, using Health Science Descriptors [DeCS] and including keywords like risk factors, diabetes and retinopathy. As a result, 9 studies were identified indicating factors associated with DR in the population with diabetes mellitus such as dyslipidemia, glycemic control, living in rural areas, hypertension, duration of diabetes, tobacco use, obesity, body mass index (BMI), glycosylated hemoglobin (HbA1c) and pre-eclampsia. In general, this work concluded that hyperglycemia, dyslipidemia and hypertension are combined throughout the diabetes course, thus determining the physiopathology underlying a diabetic retinopathy. This way, keeping an appropriate and balanced blood-pressure and glycemic control becomes the most relevant factor to reduce the risk of disease progress as a retina microvascular conditionReferences
Muñoz de Escalona-Rojas JE, Quereda-Castañeda A, García-García O. Actualización de la retinopatía diabética para médicos de atención primaria: hacia una mejora de la medicina telemática. Semergen. 2016;42(42):172-6. https://doi.org/10.1016/j.semerg.2015.06.006
Aliseda D, Berástegui L. Retinopatía diabética. Anales Sis San Navarra. 2008;31:23-34
Ting DSW, Cheung GCM, Wong TY. Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review. Clin Exp Ophthalmol. 2016;44(4):260-77
Godínez SA, Marmolejo GE, Márquez E, Siordia JJ, Baeza R. La grasa visceral y su importancia en obesidad. Revista de Endocrinología y Nutrición. 2002;10(3):121-7
McKeigue PM, Shah B, Marmot MG. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet. 1991;337(8738):382-6
Carrasco F, Galgani J. Etiopatogenia de la obesidad. Revista Médica de Clínica Las Condes. 2012;23(2):116-205. https://doi.org/10.1016/S0716-8640(12)70289-4
Raman R, Gella L, Srinivasan S, Sharma T. Diabetic retinopathy: An epidemic at home and around the world. Indian J Ophthalmol. 2016;64(1):69-75. https://doi.org/10.4103/0301-4738.178150
Bulum T, Tomić M, Duvnjak L. Total Serum Cholesterol Increases Risk for Development and Progression of Nonproliferative Retinopathy in Patients with Type 1 Diabetes Without Therapeutic Intervention: Prospective, Observational Study. Arch Med Res 2017;48(5):467-71. https://doi.org/10.1016/j.arcmed.2017.10.003
Warwick AN, Brooks AP, Osmond C, Krishnan R. Prevalence of referable, sight-threatening retinopathy in type 1 diabetes and its relationship to diabetes duration and systemic risk factors. Eye (Lond). 2017;31(2):333-41. https://doi.org/10.1038/eye.2016.294
Tyrberg M, Nyström L, Arnqvist HJ, Bolinder J, Gudbjörnsdottir S, Landin-Olsson M, et al. Overweight, hyperglycemia and tobacco use are modifiable risk factors for onset of retinopathy 9 and 17 years after the diagnosis of diabetes - A retrospective observational nation-wide cohort study. Diabetes Res Clin Pract. 2017;133:21-9. https://doi.org/10.1016/j.diabres.2017.08.009
Rudnisky CJ, Wong BK, Virani H, Tennant MT. Risk factors for progression of diabetic retinopathy in Alberta First Nations communities. Can J of Ophthalmol. 2017;52 Suppl 1:S19-S29. https://doi.org/10.1016/j.jcjo.2017.09.023
Forga L, Goñi MJ, Ibáñez B, Cambra K, García-Mouriz M, Iriarte A. Influence of age at diagnosis and time-dependent risk factors on the development of diabetic retinopathy in patients with type 1 diabetes. J Diabetes Res. 2016;2016:9898309. https://doi.org/10.1155/2016/9898309
Cleland CR, Burton MJ, Hall C, Hall A, Courtright P, Makupa WU, et al. Diabetic retinopathy in Tanzania: prevalence and risk factors at entry into a regional screening programme. Trop Med Int Health. 2016;21(3):417-26. https://doi.org/10.1111/tmi.12652
Gordin D, Kaaja R, Forsblom C, Hiilesmaa V, Teramo K, Groop P. Pre-eclampsia and pregnancy-induced hypertension are associated with severe diabetic retinopathy in type 1 diabetes later in life. Acta Diabetol. 2013;50(5):781-7. https://doi.org/10.1007/s00592-012-0415-0
Rudnisky CJ, Wong BK, Virani H, Tennant MT. Risk factors for progression of diabetic retinopathy in Alberta First Nations communities. Canadian Journal of Ophthalmology. 2012; 47:365–375
Romero-Aroca P, Baget-Bernaldiz M, Fernández-Ballart J, Plana-Gil N, Soler-Lluis N, Méndez-Marín I, et al. Ten-year incidence of diabetic retinopathy and macular edema. Risk factors in a sample of people with type 1 diabetes. Diabetes Res Clin Pract 2011;94(1):126-32. https://doi.org/10.1016/j.diabres.2011.07.004
Intramed. Diabetes Care, Nueva guía 2019 sobre diabetes (ADA) 2018 [internet]. Publicado el 19 de diciembre de 2018. Disponible en: https://www.intramed.net/contenidover.asp?contenidoid=93549. [Consultado el 28 de marzo de 2020]
Ometto G, Assheton P, Calivá F, Chudzik P, Al-Diri B, Hunter A, et al. Spatial distribution of early red lesions is a risk factor for development of vision-threatening diabetic retinopathy. Diabetologia. 2017;60(12):2361-7. https://doi.org/10.1007/s00125-017-4424-y
Scanlon PH, Stratton IM, Bachmann MO, Jones C, Leese GP; Four Nations Diabetic Retinopathy Screening Study Group. Risk of diabetic retinopathy at first screen in children at 12 and 13 years of age. Diabet Med. 2016 Dec;33(12):1655-1658. doi: 10.1111/dme.13263. Epub 2016 Oct 19. PMID: 27646856; PMCID: PMC5434868
Bertelsen G, Peto T, Lindekleiv H, Schirmer H, Solbu MD, Toft I, Sjølie AK, Njølstad I. Tromsø eye study: prevalence and risk factors of diabetic retinopathy. Acta Ophthalmol. 2013;91(8):716-21. https://doi.org/10.1111/j.1755-3768.2012.02542.x
Salardi S, Porta M, Maltoni G, Cerutti F, Rovere S, Iafusco D, et al. Ketoacidosis at diagnosis in childhood-onset diabetes and the risk of retinopathy 20 years later. J Diabetes Complications. 2016;30(1):55-60. https://doi.org/10.1016/j.jdiacomp.2015.10.009
Mowatt L. Diabetic retinopathy and its risk factors at the University Hospital in Jamaica. Middle East Afr J Ophthalmol. 2013;20(4):321-6. https://doi.org/10.4103/0974-9233.120017
Keywords
diabetes
retinopathy